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That is because in all patients, no matter what their Her2/neu status, Herceptin increases the of heart dysfunction. Otherwise, the risk of heart failure is just too great to justify use of this drug.
At least the test is actually being used and has some benefit, unlike CYP450 gene testing (Katsanis et al., 2008).
The CYP450 genes code for a large family of proteins known as the cytochrome P450 enzymes.
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